The CloDif-Tx qPCR Panel-2 comprises a series of specific targeted reagents designed for Clostridioides difficile Toxin A (tcdA) and Toxin B (tcdB) detection by using qPCR. Clostridioides difficile (formerly Clostridium difficile) is a Gram-positive, spore-forming, anaerobic bacillus belonging to the family Peptostreptococcaceae.

It is a major causative agent of antibiotic-associated diarrhoea and pseudomembranous colitis, which primarily affects humans but also various animals, including livestock and pets. Clinical manifestations range from mild diarrhoea to severe colitis, with symptoms such as abdominal pain, fever, and dehydration, often linked to disruption of the normal gut microbiota following antibiotic use. Transmission occurs through the faecal-oral route, with spores persisting in the environment and facilitating nosocomial and community-acquired infections. C. difficile is distributed globally and represents a significant public health concern, particularly in healthcare settings. Toxins A and B are primary virulence factors with a cytotoxic effect that are responsible for the pathogenesis of C. difficile infection, contributing to intestinal inflammation and tissue damage.

Kit Content and Prices

F100

MONODOSE